Stem Cell Therapy for Osteoarthritis

Revision Knee Surgery

Dr. Marc Darrow

Stem Cell Therapy for Osteoarthritis

When a patient comes into our office who has osteoarthritis, we see a degenerative disease of “no cartilage,” “bone-on-bone”, osteocronosis and necrosis (bone death) and usually this patient carries with them a surgical recommendation for joint replacement that they do not want.

Why are they here in our office? Because we are one of the few clinics that offer stem cell therapy injections for osteoarthritis. Mesenchymal stem cells (these are stem cells typically drawn from the bone marrow of the patient or sometimes from fat cell – see the video below) have been researched and shown to be a realistic treatment for repairing cartilage damage.

Recently doctors in South Korea have been publishing large amounts of data on the benefits of stem cell therapy. In 2014 doctors from Seoul National University College of Medicine published their research on the validity of stem cell therapy for knee osteoarthritis. In that research the doctors too stem cells out of the surgical procdure and introduced them into the patient’s damaged knee by injection (as we do here in our office). What they found was the stem cell injections regenerated cartilage in osteoarthritic knees.1

There is so much research centered on stem cell therapy for osteoarthritis because doctors have long known that fixing diseased or damaged articular cartilage in patients is still a challenge despite advances in surgery and MRI diagnosis. This is why mesenchymal stem cells are being studied for their regenerative properties and why research like that above is so exciting . In related research not only did injected stem cells begin the healing process, but they also mobilized the “native” stem cells start repairing damage through “signalling” or the paracrine effect where the healing environment of the whole joint was switched on and in one animal study documented bone growth.2

In our practice we specialize in treatments that rebuild, rejuvenate, and strengthen joints effected by osteoarthritis. Not only do Mesenchymal stem cells (MSCs) have the potential to stop the degenerative process of Osteoarthritis they have the ability to rebuild articular cartilage, tendons, ligaments, and other soft tissue.

“With an aging population, the prevalence of osteoarthritis has increased. Mesenchymal Stem Cells (MSCs) have been proposed to be an attractive alternative candidate in the tissue engineering of articular cartilage primarily due to its abundant source, reduced cartilage donor site morbidity, and strong capacity for proliferation and potential to differentiate toward a chondrogenic phenotype (make cartilage).”3


Adult stem cells are extracted from the patient’s own body and used to create a healing solution containing platelet-rich plasma and stem cells. This is done in accordance with FDA guidelines that prohibit manipulation of the stem cells. Once injected into degenerated joints and ligaments, your own newly activated stem cells go to work causing a dynamic self-repair response on the cellular level.

Adult Stem Cell Therapy has the potential to provide joint, tendon, ligament, and muscle regeneration, and is the next frontier for Prolotherapy and PRP. Treat painful back and joint problems with Adult Stem Cell Therapy. Learn more today!

Contact Us

Please Call Us or Email TODAY!
  • This field is for validation purposes and should be left unchanged.

1. Jo CH, Lee YG, Shin WH, Kim H, Chai JW, Jeong EC, Kim JE, Shim H, Shin JS, Shin IS, Ra JC, Oh S, Yoon KS. Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial. Stem Cells. 2014 May;32(5):1254-66. doi: 10.1002/stem.1634.
2. Linero I, Chaparro O. Paracrine effect of mesenchymal stem cells derived from human adipose tissue in bone regeneration. PLoS One. 2014 Sep 8;9(9):e107001. doi: 10.1371/journal.pone.0107001. eCollection 2014.
3. Tang QO, Carasco CF, Gamie Z, Korres N, Mantalaris A, Tsiridis E. Preclinical and clinical data for the use of mesenchymal stem cells in articular cartilage tissue engineering. Expert Opin Biol Ther. 2012 Oct;12(10):1361-82. Epub 2012 Jul 12.